Feasibility of Cardiac Exercise Rehabilitation in Patients with Cardiac Amyloidosis
Keywords:AL amyloidosis, amyloidosis, ATTRv amyloidosis, ATTRwt amyloidosis, cardiac exercise rehabilitation
Objective: We aimed to determine if cardiac exercise rehabilitation was feasible and beneficial in patients with cardiac amyloidosis.
Methods: This prospective single-centre pilot study was proposed to all adult patients, diagnosed with cardiac amyloidosis, and referred to the cardiac rehabilitation centre at the Henri Mondor University hospital (Créteil, France) between 2011 to 2015. All patients had clinical evaluations, laboratory tests, and echocardiographic examinations when presenting at the hospital. The cardiac exercise rehabilitation programme, in this study, comprised a baseline incremental system-limited exercise test followed by 20 endurance training sessions at a constant workload. Cardiac exercise rehabilitation was feasible if the patient completed the baseline test and ≥10 sessions without an exercise limiting adverse event. Patients with a relative increase of ≥16% in in VO2 max and/or maximal workload were considered to have benefited from cardiac exercise rehabilitation.
Results: Overall, 27 cardiac amyloidosis patients were recruited. Cardiac exercise rehabilitation was feasible in 19 (70%) and not feasible in 8 (30%). Of the 19 patients where cardiac exercise rehabilitation was feasible, cardiac exercise rehabilitation benefited 9 (47%). This benefit was significantly associated with lower N-type pro-brain natriuretic peptide levels, lower creatinineamia, and higher left ventricular ejection fraction at baseline.
Conclusion: Cardiac exercise rehabilitation is feasible and beneficial in selected patients with cardiac amyloidosis.
Copyright (c) 2023 Thibaud Damy, Barnabas Gellen, Silvia Oghina, Mijiti Wuliya, Habib Ben Eljah, Soulef Guendouz, Sandrine Peyrot, Pierre Vladimir Ennezat, Luc Hittinger, Emmanuel Teiger, Laura Ernande, Florence Canoui-Poitrine
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