Feasibility of Cardiac Exercise Rehabilitation in Patients with Cardiac Amyloidosis
DOI:
https://doi.org/10.52057/erj.v3i1.27Keywords:
AL amyloidosis, amyloidosis, ATTRv amyloidosis, ATTRwt amyloidosis, cardiac exercise rehabilitationAbstract
Objective: We aimed to determine if cardiac exercise rehabilitation was feasible and beneficial in patients with cardiac amyloidosis.
Methods: This prospective single-centre pilot study was proposed to all adult patients, diagnosed with cardiac amyloidosis, and referred to the cardiac rehabilitation centre at the Henri Mondor University hospital (Créteil, France) between 2011 to 2015. All patients had clinical evaluations, laboratory tests, and echocardiographic examinations when presenting at the hospital. The cardiac exercise rehabilitation programme, in this study, comprised a baseline incremental system-limited exercise test followed by 20 endurance training sessions at a constant workload. Cardiac exercise rehabilitation was feasible if the patient completed the baseline test and ≥10 sessions without an exercise limiting adverse event. Patients with a relative increase of ≥16% in in VO2 max and/or maximal workload were considered to have benefited from cardiac exercise rehabilitation.
Results: Overall, 27 cardiac amyloidosis patients were recruited. Cardiac exercise rehabilitation was feasible in 19 (70%) and not feasible in 8 (30%). Of the 19 patients where cardiac exercise rehabilitation was feasible, cardiac exercise rehabilitation benefited 9 (47%). This benefit was significantly associated with lower N-type pro-brain natriuretic peptide levels, lower creatinineamia, and higher left ventricular ejection fraction at baseline.
Conclusion: Cardiac exercise rehabilitation is feasible and beneficial in selected patients with cardiac amyloidosis.
Downloads
Published
License
Copyright (c) 2023 Thibaud Damy, Barnabas Gellen, Silvia Oghina, Mijiti Wuliya, Habib Ben Eljah, Soulef Guendouz, Sandrine Peyrot, Pierre Vladimir Ennezat, Luc Hittinger, Emmanuel Teiger, Laura Ernande, Florence Canoui-Poitrine
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
The Licence is describe as: Attribution-NonCommercial-NoDerivatives 4.0 International(CC BY-NC-ND 4.0)
You are free to:
- Share — copy and redistribute the material in any medium or format
- The licensor cannot revoke these freedoms as long as you follow the license terms.
Under the following terms:
-
Attribution — You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
-
NonCommercial — You may not use the material for commercial purposes.
-
NoDerivatives — If you remix, transform, or build upon the material, you may not distribute the modified material.
- No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.
